估计阅读时长: 14 分钟https://github.com/xieguigang/sciBASIC 层次聚类通过计算不同类别数据点间的相似度来创建一棵有层次的嵌套聚类树。基于层次聚类分析,我们可以初步可视化我们的一些原始数据: 例如对样本的层次聚类分类,可以让我们了解到样本在分组之间以及分组内的异质性。 对生物序列进行基于相似度的层次聚类分析,我们可以了解到序列之间的相似性程度或者进化关系 Order by Date Name Attachments metabolome • 14 kB • 653 click […]
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Thank you so much for your thoughtful and encouraging comment! I truly appreciate the time you took to read through…
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A very inspiring pipeline for turning EC-based annotations into genome-scale embeddings. Great post! I really enjoyed the clear, end‑to‑end pipeline…
[…] 基于之前的一篇文章《TF-IDF与N-gram One-hot文档嵌入算法原理》的学习,我们了解到可以将生物序列通过分解为kmer,组成单词集合用来表示一个文档。从而将长度各异的生物序列嵌入为长读一致的数值向量,进而可以用于后续的各种数据处理工作中。在这里,假设我们将基因组中的所有基因提取出来,然后通过blast比对的方式将基因注释到对应的ec number编号,既可以将某一个基因组使用一个ec number的集合来表示。通过这样子的数据表示方法,我们就可以将任意一个大小各异,基因组成不同的基因组都嵌入为具有相同维度特征的数值向量用于机器学习建模之类的工作。 […]
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